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The cake was lacking in substance.
She was accused of possession of illegal substances.

"}},{"@type":"Question","name":"What are the synonyms of \"substance\"?","acceptedAnswer":{"@type":"Answer","text":"

chemical: a substance used in or produced by chemistry, related to chemistry
compound: a substance formed from two or more elements, a mixture
matter: something that is to be done, discussed, or dealt with; subject of a discourse, discussion, or writing
nature: essence, natural world, character, disposition

"}},{"@type":"Question","name":"What are the antonyms of \"substance\"?","acceptedAnswer":{"@type":"Answer","text":"

emptiness: the state of containing nothing; lack of content
insubstantiality: lack of substance; unimportance

"}}]}